Biotronik Se Co. Kg

Portland State University

Ravi Kiran Kondama Reddy

R Hollis Whittington

Shayan Guhaniyogi

Madeline Anne Midgett

Christopher Jones

Dirk Muessig

Kurt Swenson

Shalini Prasad

Thomas Doerr

Larry Stotts

A leadless pacemaker device configured to provide for an intra-cardiac pacing, including: processing circuitry configured to generate ventricular pacing signals for stimulating ventricular tissue, and a reception device for receiving a sensing signal indicative of an atrial activity, wherein the processing circuitry is configured to detect an atrial event derived from said sensing signal, wherein the atrial event is a valid atrial sense event, where a series of atrial events lie within a range for a normal atrial rate, and/or when the atrial rate variability is within a certain range indicating a regular atrial rhythm, wherein in case a valid atrial sense event is detected, the processing circuitry is further configured to: determine ventricular pacing events according to atrial events, calculate ventricular-atrial time delays, determine a correction value based a measured time delay and the calculated time delay, and adjust the ventricular pacing timing based on the correction value.

Leadless cardiac pacemaker device configured to provide intra-cardiac pacing

An active medical device, comprising a processor, a memory unit, and at least one of an accelerometer and a detection unit configured to detect a body impedance. During operation, the active medical device carries out the following steps: a) measuring a body impedance of a patient with the detection unit during a first period of time to obtain time-dependent impedance data and calculating a power spectral density of the impedance data; b) alternatively or additionally to step a), measuring an acceleration of a body of the patient with the accelerometer during the first period of time to obtain time-dependent acceleration data and calculating a power spectral density of the acceleration data; c) identifying coughing of the patient on the basis of the calculated power spectral density if at least 1% of all values of the power spectral density have a frequency of at least 1 Hz.

Active medical device capable of identifying coughing

A leadless pacemaker device configured to provide for an intra-cardiac pacing, including: processing circuitry configured to generate ventricular pacing signals for stimulating ventricular activity, and a reception device for receiving a sensing signal indicative of an atrial activity, wherein the processing circuitry is configured to detect an atrial event derived from said sensing signal, wherein the atrial event is a valid atrial sense event, where a series of atrial events lie within a range for a normal atrial rate, and/or when the atrial rate variability is within a certain range indicating a regular atrial rhythm, wherein in case a valid atrial sense event is detected, the processing circuitry is further configured to: determine ventricular pacing events according to atrial events, calculate ventricular-atrial time delays, determine a correction value based a measured time delay and the calculated time delay, and adjust the ventricular pacing timing based on the correction value.

A leadless pacemaker device for providing an intra-cardiac pacing includes processing circuitry configured to generate ventricular pacing signals for stimulating ventricular activity at a ventricular pacing rate, a first sensor configuration receiving a first sense signal, and a second sensor configuration receiving a second sense signal. The processing circuitry derives, in a first sensing state, atrial events from the first sense signal for controlling the ventricular pacing rate based on the atrial events. The processing circuitry switches, based on at least one switching criterion, from the first sensing state to a second sensing state in which the processing circuitry derives atrial events from the second sense signal. The second sense signal is received by the second sensor configuration for detection of atrial events and the second sensor configuration is a motion sensor or a sound sensor. A method for operating the pacemaker device is also provided.

Sensors include nano-porous alumina membranes that are sensitized by immobilization of antibodies in the nano-pores. The nano-membranes can be sensitized to respond to a single target compound, or different portions of the nano-membrane can be differently sensitized. Capture of the target compound can be detected based on a spectral signature associated with electrical conductance in the nano-pores.

Growing community of inventors

Portland, OR, United States of America

Ravi Kiran Kondama Reddy