General Electric Company

Ravi Hedge

Ramesh Venkatesan

Arun Balasubramanian

Ritika Uppal Mukherjee

Chandan Ramaswamy Atreya

The present invention provides an in-vitro method for detecting the presence of a target substance in a biological sample by magnetic resonance, the method comprising: a) providing a mixture comprising a biological sample and a plurality of magnetic nanoparticles, wherein the magnetic nanoparticles comprise a binding agent capable of binding the target substance when the target substance is present in the biological sample; and b) determining a Trelaxation time corresponding to magnetic nanoparticles that are bound to the target substance (T) in the sample; wherein Tdiffers from the Trelaxation time corresponding to the magnetic nanoparticles that are not bound to the target substance (T), and wherein Tis determined without physically separating magnetic nanoparticles that are bound to the target substance from the magnetic nanoparticles that are not bound to the target substance.

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Bengaluru, India

Ravi Hedge