Codexis, Inc.

Societe Des Produits Nestle S.a.

Soci&#xc9;t&#xc9; Des Produits Nestl&#xc9; S.a.

Ravi David Garcia

Nikki Dellas

David Entwistle

Oscar Alvizo

Jovana Nazor

Jack S Liang

Jonathan Vroom

Charlene Ching

Xiyun Zhang

Jeffrey C Moore

Vesna Mitchell

Rama Voladri

Birgit Kosjek

Robert Osborne

Shane Grosser

Matthew Truppo

Scott J Novick

David Elgart

Chinping Chng

Robert Kevin Orr

Courtney Dianne Moffett

Katrina W Lexa

Judy Victoria Antonio Viduya

James Nicholas Riggins

Da Duan

Xiang Yi

Harvinder Chagger Maniar

Stephanie Sue Galanie

Nandhitha Subramanian

Kristen Jean Vallieu

Moulay Hicham Alaoui Ismaili

Kerryn McCluskie

The present invention provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The invention also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.

Engineered transaminase polypeptides for industrial biocatalysis

The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Engineered proline hydroxylase biocatalysts for hydroxylation of chemical compounds

The present application provides engineered glucose dehydrogenase polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds

The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH<7) conditions. The invention also relates to the use of the compositions comprising the engineered amylase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered amylase polypeptides, as well as methods for making the engineered polynucleotides and amylase polypeptides.

Engineered amylase variants

The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

Penicillin-G acylases

The present invention provides engineered protease polypeptides and compositions thereof. The engineered protease polypeptides have been optimized to provide improved activity, improved thermostability, protease stability, autolytic stability, and stability under a range of pH conditions, including acidic (pH<7) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered protease polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered protease polypeptides, as well as methods for making the engineered polynucleotides and protease polypeptides.

Engineered protease variants

The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH&#x3c;7) conditions. The invention also relates to the use of the compositions comprising the engineered amylase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered amylase polypeptides, as well as methods for making the engineered polynucleotides and amylase polypeptides.

Vectors for expression of biocatalysts

The present invention provides engineered &#x3b2;-glucosidase (BGL) enzymes, polypeptides having BGL activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the enzymes, and methods of using the engineered BGL enzymes to make products with &#x3b2;-glucose linkages.

Engineered beta-glucosidases and glucosylation methods

The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides. Methods for producing PAL enzymes are also provided. In some embodiments, the engineered PAL polypeptides are optimized to provide enhanced catalytic activities that are useful under industrial process conditions for the production of pharmaceutical compounds.

Engineered phenylalanine ammonia lyase polypeptides

Polynucleotides encoding biocatalysts and methods for hydroxylation of chemical compounds

Growing community of inventors

Los Gatos, CA, United States of America

Ravi David Garcia