Prelude Therapeutics Incorporated

Raul A Leal

Rupa S Shetty

Andrew Paul Combs

Juan Luengo

Jincong Zhuo

Liang Lu

Hong Lin

Chaofeng Dai

Klare Lazor Bersch

Krishna Vaddi

Peng Wei

The disclosure is directed to, in part, to CDK inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.

CDK inhibitors and their use as pharmaceuticals

The disclosure is directed to compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, or Formula VI: Methods of their use in inhibiting a protein arginine methyltransferase 5 (PRMT5) enzyme and treating disease, as well as methods of their preparation are also described. 

Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)

The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I as well as methods of their use and preparation, are also described.

Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein

Growing community of inventors

Newark, DE, United States of America

Raul A Leal