Bayer Aktiengesellschaft

Rathindra Das

Michael Schedel

Dietrich Horlein

Jurgen Ebbers

Hans Fritz

Wolfgang Gebhard

A proteinase inhibitor which has the sequence of amino acids 21 to 147 of human bikunin, in which at least one amino acid residue has been replaced by another naturally occurring amino acid. Such proteinase inhibitor is useful in pharmaceutical compositions.

Human Bikunin variants as proteinase inhibitors, and medicaments

An aprotinin with a deletion of the amino acid proline in position 2 or an addition of alanine-(-2)-glutamine-(-1). Such aprotinin is useful as an active ingredient in medicaments.

Recombinant aprotinin variants genetically engineered process for the

An aprotinin with a deletion of the amino acid proline in position 2 or an addition of alanine-(-2)- glutamine-(-1). Such aprotinin is useful as an active ingredient in medicaments.

Growing community of inventors

Wuppertal, Germany

Rathindra Das