Biomark Technologies, Inc.

Biomark Cancer Systems Inc.

Rashid Bux

Brian K Cheng

Daniel Sitar

Reuven Gordon

Fraser Hof

Brian Cheng

Aftab Ahmed

Bram Ramjiawan

Fraser Alan Hof

Daniel S Sitar

A method for assaying activity of the enzyme spermidine/spermine N-acetyltransferase (SSAT) uses SSAT substrates by detecting their acetylated forms. SSAT substrates may include rimantadine and tocainide wherein their metabolism occurs in part by the action of the inducible enzyme SSAT to produce the acetylated metabolites N-acetylrimantadine and N-acetyltocainide respectively. SSAT activity may be correlated to pathologic conditions.

Method for assaying the activity of spermidine/spermine N1-acetyltransferase

A biomarker panel for a urine test for detecting lung cancer detects a biomarker selected from the group of biomarkers consisting of DMA, C5:1, C10:1, ADMA, C5-OH, SDMA, and kynurenine, or a combination thereof. A biomarker panel for a serum test for detecting lung cancer detects a biomarker selected from the group of biomarkers consisting of valine, arginine, ornithine, methionine, spermidine, spermine, diacetylspermine, C10:2, PC aa C32:2, PC ae C36:0, and PC ae C44:5; and lysoPC a C18:2, or a combination thereof.

Method of detecting lung cancer

[object Object]

A method for quantifying acetylamantadine in a urine sample comprises eluting acetylamantadine from the urine sample using solid phase extraction and quantifying the acetylamantadine eluted from the urine sample using Raman spectroscopy.

Detection and quantification of acetylamantadine in urine samples

Growing community of inventors

Vancouver, Canada

Rashid Bux