Eka Chemicals Ab

Commissariat a L'energie Atomique

Eka Chemicals

Raphaël Duval

Hubert Leveque

Yves Barre

Roger Neige

Marc Simon

There are described novel cross-linked polymers based on bis-silane, bis-thioether, bis-sulphoxide, bis-sulphone and butane-di-yl derivatives of polysaccharides and oligosaccharides, their shaping as support materials useful for the separation or preparation of enantiomers; a process for preparing the said cross-linked polymer compounds, a process for preparing balls of support materials containing the said cross-linked polymer compounds; a method of obtaining balls of support materials useful in chromatography or in organic synthesis; and the use of the said support materials containing the cross-linked polymer compounds in separation or in preparation of enantiomers, through employment in chromatography or organic synthesis processes in a heterogeneous medium; and the use of the said cross-linked polymer compounds in the form of membranes in processes using percolation through membranes for the separation or the preparation of enantiomers.

Cross-linked polymers based on bis-silane, bis-thioether, bis-sulphoxide, bis-sulphone and butane-di-yl derivatives of polysaccharides and oligosaccharides, and their shaping as support materials

This invention relates to optically active support materials which include one or more esters and/or one or more carbamates and/or one or more mixed ester and carbamate compounds of polysaccharide or oligosaccharide, and an organic and/or inorganic substrate.

Optically active support materials, their method of preparation and their uses

The invention concerns a crosslinked optically active three-dimensional polymer network, consisting of homochiral units of a first selector and of homochiral units of at least a second selector of different structure from the first selector, the homochiral units of the first selector comprising at least three polymerisable or crosslinkable functional groups and the homochiral units of the second selector comprising at least two polymerisable or crosslinkable functional groups, the homochiral groups being chemically mutually bound. The invention also concerns a method for making such a polymer network and its uses.

Crosslinked three-dimensional polymer network, method for preparing same, support material comprising same and uses thereof

The invention relates to ureido or carbamate derivatives of crown ethers and of silicon of formula: These derivatives can be grafted to silica gel for the purpose of obtaining supports for the chromatographic separation of cations or of molecules comprising amine functional groups, such as amino acids.

Ureido or carbamate derivatives of crown ethers and of silicon usable for preparing supports intended for the separation by chromatography of metal cations and of organic molecules comprising amine functional groups

The invention relates to a method which comprises synthesizing bifunctional compounds then chiral compounds from the bifunctional compounds, also to synthesizing supports comprising these chiral compounds, and the use of these supports for preparing or separating enantiomers, or for asymmetric synthesis. The invention also relates to bifunctional compounds, their use as a source of functionalized polymers, and to the chiral compounds, also to the use of these chiral compounds in a chiral support in the form of a three-dimensional network or for separating or preparing enantiomers, principally for analytical or preparative chromatography, and in a support for the production of chiral molecules by asymmetric synthesis.

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Deauville, France

Raphaël Duval