Université De Bretagne Occidentale

Centre National De La Recherche Scientifique

Guerbet

Ecole Normale Superieure De Lyon

Cnrs—centre National De La Recherche

Université Claude Bernard Lyon 1 (ucbl1)

Centre National De La Recherche Scientifique-cnrs

Raphaël Tripier

Maryline Beyler

Olivier Rousseaux

Mariane Le Fur

Fatima Oukhatar

Olivier Maury

Olivier Fougère

Carlos Platas-Iglesias

Luis Lima

Nathalie Camus

Nadège Hamon

Gwladys Nizou

Janah Shaya

Zakaria Halime

Nicolas Le Poul

Hélène Bernard

Amélie Forget

Disclosed are chelates resulting from the complexation of bifunctional do2pa derivatives ligands of formula (I), wherein the substituents R, R, R, R, R, R, L, L, Land Lare defined as in the claims, with metallic cations, especially Pb(II) and Bi(III). Also disclosed are bifunctional do2pa derivatives ligands of formula (I), as well as the use of chelates in nuclear medicine and the use of ligands in cations detection or epuration of effluents.

Bifunctional do2pa derivatives, chelates with metallic cations and use thereof

A ligand of Formula (A): wherein each Rindependently represents a chromophore group; L, Land Leach independently represents a single bond or a linker; and X, Xand Xeach independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.

Pyclen-based macrocyclic ligands, chelates thereof and uses thereof

Disclosed are chelates resulting from the complexation of bifunctional do2pa derivatives ligands of formula (I), wherein the substituents R, R, R, R, R, R, L, L, Land Lare defined as in the claims, with metallic cations, especially Pb(II) and Bi(III). Also disclosed are bifunctional do2pa derivatives ligands of formula (I), as well as the use of chelates in nuclear medicine and the use of ligands in cations detection or epuration of effluents. 

Ligands that are based on the pyclen macrocycle that are reinforced, which are useful for complexing elements such as radioelements and/or elements with magnetic properties.

Reinforced macrocyclic ligands, complexes thereof, and uses of same

A macrocycle compound of general formula (X) in which Yrepresents a C(O)OH group or a group of formula (II) 

Macrocyclic ligands with picolinate group(s), complexes thereof and also medical uses thereof

The present invention relates to compounds, ligands, and/or complexes that are useful in medical imaging and/or in therapy, especially in cancer treatment. The present invention also relates to a pharmaceutical composition comprising said compounds, ligands, and/or complexes that are useful for medical imaging, targeting, and/or treatment of cancers. The present invention also relates to a process for preparing these compounds, ligands, and/or complexes.

Macrocylic ligands with picolinate group(s), complexes thereof and also medical uses thereof

Chelates resulting from the complexation of picolinate cross-bridged cyclams of formula (I), wherein n and the substituents L1-L4 and R1-R5 are as defined, with metallic cations. Picolinate cross-bridged cyclam ligands of formula (I), the use of chelates in nuclear medicine and the use of ligands in cations detection or epuration of effluents are also described.

Picolinate cross-bridged cyclams, chelates with metallic cations and use thereof

The invention relates to a chelate resulting from the complexing of a trans-di-N-picolinate tetraazacycloalkane ligand with a metal cation, said ligand corresponding to formula (A) wherein n is equal to 0 or to 1, R is H or a C1-C18 alkyl radical, and R' is H or a C1-C18 alkyl radical, said metal cation being a cation of a metal selected from the group consisting of lead (II) and bismuth (III). The invention is applicable in the field of lead trapping and alpha-radioimmunotherapy. 

Chelates of lead (II) and bismuth (III) based on trans-di-N-picolinate tetraazacycloalkanes

Special C-functionalized cyclic bisaminal compounds having formula (I) or (II), their salts or solvates, methods for their preparation, their uses, and methods for preparing functional tetraazacycloalkane compounds implementing such cyclic bisaminal compounds.

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Kersaint Plabennec, France

Raphaël Tripier