Centre National De La Recherche Scientifique

Pharmagap Inc.

Raphael Terreux

Jenny Phipps

Sylvie Marianne Nessler

Philippe Roger Meyer

Alain Jean Cozzone

Christophe Louis Antoine Grangeasse

Solange Rose Theodora Morera

A compound comprising a peptide moiety comprising, consisting essentially of, or consisting of, the peptide sequence of a tyrosine cluster YC of the BY-kinase of a Gram positive or Gram negative bacteria, or a fragment or an analogue thereof, and an adenine peptide analogue PNA(A), whereas the peptide moiety and the PNA are linked together. The compound is useful as an inhibitor of bacterial tyrosine kinase.

Inhibitors of bacterial tyrosine kinase and uses thereof

Compounds that are capable of inhibiting the activity of one or more protein kinases are provided. The compounds are short, predominantly basic peptidic compounds comprising between about 5 and about 20 amino acids, and can optionally comprise an ATP mimetic moiety. The protein kinase inhibiting compounds can be used to inhibit the activity of one or more protein kinases in vitro or in vivo. Also provided are methods of inhibiting a protein kinase in a subject by administration of an effective amount of a protein kinase inhibiting compound and the use of the protein kinase inhibiting compounds, alone or in combination with other chemotherapeutic agents, in the treatment of protein kinase mediated diseases and disorders. 

Inhibitors of protein kinases and uses thereof

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Lyons, France

Raphael Terreux