Epix Delaware, Inc.

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Teva Pharmaceutical Industries Limited

Raphael Nudelman

Oren Becker

Srinivasa Rao Cheruku

Yael Marantz

Dale S Dhanoa

Silvia Noiman

Dongli Chen

Boaz Inbal

Anurag Sharadendu

Pradyumna Mohanty

Alexander Heifetz

Shay Bar-Haim

Merav Fichman

Sharon Shacham

Abraham Jacob Domb

Jeffrey Sterling

Yaacov Herzig

Eliezer Falb

Konstantin Ulanenko

Sharon Shachem

Disclosed are novel derivatives of propargyl-trifluoromethoxy-amino-benzothiazole which are effective in treating neurologic disorders, including Parkinson's disease and multiple sclerosis.

Propargyl-trifluoromethoxy-aminobenzothiazole derivatives, their preparation and use

The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formula I, and synthesis and uses thereof for treating diseases including those mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as generalized anxiety disorder, ADD/ADHD, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

Arylpiperazinyl compounds

The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formulae I: and II, and synthesis and uses of those compounds for treating diseases including those mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as generalized anxiety disorder, ADD/ADHD, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

A monomeric diacid derivative includes at least two fatty acids coupled by hydrolytically or enzymatically degradable bond. In a biological environment, the bond degrades forming naturally occurring fatty acid products thereby allowing elimination.

Biopolymers derived from hydrolyzable diacid fats

A monomeric diacid derivative includes at least two fatty acids coupled by a hydrolytically or enzymatically degradable bond. In a biological environment, the bond degrades forming naturally occurring fatty acid products thereby allowing elimination.

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Rehovot, Israel

Raphael Nudelman