Les Laboratoires Servier

Chanel Parfums Beaute

Université De Lille

Les Laboratories Servier

Raphaël Lebeuf

Jean-Pierre Lecouve

Christophe Hardouin

Vincent Levacher

Jean-Marie Aubry

Christian Mahe

Maxime Nollet

Jean-François Briere

Oriana Boucenna Verdier

Véronique Rataj-Nardello

Jean-Françoís Briere

Disclosed is a microemulsion of oil-in-water type including, preferably consisting of, by weight relative to the total weight of microemulsion: &#x2022;70% to 94% of water, &#x2022;1% to 15% of at least one hydrophobic fragrancing substance, &#x2022;4% to 20% of at least one preferably volatile solvo-surfactant, and &#x2022;0.1% to 15%, preferably 1% to 13%, of at least one hydrotropic agent or at least one surfactant selected from anionic surfactants, cationic surfactants, amphoteric surfactants and non-ionic surfactants. The solvo-surfactant is selected from monoalkylated glycerol derivatives of following formula (I): wherein the 'alkyl' group is a linear or branched alkyl group including from 1 to 8 carbon atoms, and R and R' are each independently H or a linear or branched alkyl group including from 1 to 5 carbon atoms, with the proviso that R is different from R&#x2032;, and mixtures thereof.

Perfumes in the form of aqueous microemulsions

Process for the industrial synthesis of the compound of formula (I): 

Process for the synthesis of 7-methoxy-naphthalene-1-carbaldehyde and application in the synthesis of agomelatine

Process for the synthesis of agomelatine

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Lille, France

Raphaël Lebeuf