Grandis, Inc.

Université Libre De Bruxelles

Facultés Universitaires Notre-Dame De La Paix

Raphaël Frédérick

Gwenaël Dehon

Daniel Labar

Pierre Sonveaux

Vincent Van Hée

Robert Kiss

Bernard Masereel

Celine Bruyere

Céline Anne Marie Michelle Meinguet

Véronique Emmanuelle Julie Mathieu

Jeremy Reniers

Johan Wouters

A positron emission tomography (PET) radiotracer for imaging lactate uptake, wherein the tracer is [F]-3-fluoro-2-hydroxypropionic acid, or a pharmaceutical acceptable salt and/or solvate thereof. Also, a process for the radiosynthesis of [F]-3-fluoro-2-hydroxypropionic acid, or a pharmaceutical acceptable salt and/or solvate thereof. Further, the use of [F]-3-fluoro-2-hydroxypropionic acid, or a pharmaceutical acceptable salt and/or solvate thereof, for imaging lactate uptake in living cells, especially in humans.

[18F]-labelled lactate derivative as PET radiotracer

A positron emission tomography (PET) radiotracer for imaging lactate uptake, wherein the tracer is a [F]-labelled lactate derivative which is [F]-3-fluoro-2-hydroxypropionic acid: Also, a process for the radiosynthesis of the [F]-labelled lactate derivative. Further, the use of the [F]-labelled lactate derivative for imaging lactate uptake in living cells, especially in humans.

[F]-labelled lactate derivative as pet radiotracer

The invention provides novel beta-carboline derivatives of formulae (Ia) and (Ib) useful in the treatment of proliferative disorders including cancer, intermediates used in their preparation, processes for preparing the same and uses thereof. 

Beta carboline derivatives useful in the treatment of proliferative disorders

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Godinne, Belgium

Raphaël Frédérick