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Pfizer Corporation

Institut Francais Du Pe'trole

Chiralsep S.a.r.l.

Raphael Duval

Hubert Leveque

Laurent Berger

Ingo Weber

Alexander Wick

Philippe Taillasson

A process for producing substantially optically pure sertraline utilizes chromatographic separation on a solid stationary chiral phase of spherical clay particles having an interlayer containing an optically pure metal-organic complex, and a liquid mobile phase preferably containing at least methyl acetate. The liquid mobile phase is preferably free of acetonitrile. The process is operable at temperatures above 40&deg; C.

Process for the preparation of optically pure or enriched racemic tetralone

There are described chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides as novel compounds which are polymerizable and cross-linkable, and a method for obtaining them; novel support materials obtained from said derivatives and containing said silane derivatives of polysaccharides or oligosaccharides chemically grafted by a covalent bond with the support and polymerized and cross-linked in a three-dimensional network and a method for obtaining them; as well as the use of said material supports in separation or in preparation of enantiomers, through employment in gaseous, liquid or supercritical chromatography, by electrophoresis, electrochromatography or by percolation processes through membranes containing said support materials.

Chloro-, hydroxy- and alkoxysilane derivatives of polysaccharides or oligosaccharides, polymerizable and cross-linkable, their synthesis and their use as sources of novel support materials

Mono- and di-derivatives of cyclodextrins are completely defined, also a method for their synthesis and purification, functionalised cyclodextrins obtained from these derivatives, and the synthesis of supports comprising these cyclodextrin derivatives. Use of the supports for the preparation of separation of enantiomers, for asymmetric synthesis, for catalysis, for the preparation or separation of geometrical isomers or positional isomers, or for the preparation or separation of organic molecules with a hydrophobic nature is also described.

Mono-  and di-derivatives of cyclodextrins, synthesis thereof and

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Notre Dame de Gravenchon, France

Raphael Duval