Xencor, Inc.

Raphael Clynes

John R Desjarlais

Matthew J Bernett

Rajat Varma

Christine Bonzon

Suzanne Schubbert

Provided herein are dimeric IL-7-Fc fusion proteins that include Fc domains and one or more IL-7s. Also provided herein are variant IL-7s with modifications to reduce heterogeneity and/or reduced affinity/potency. Such variant IL-7s are useful, for example, in the subject dimeric IL-7-Fc fusion proteins. The dimeric IL-7-Fc fusion proteins can be used for applications where increased IL-7 activity is useful, for example, for increasing the proliferation of lymphocyte populations in mounting an anti-tumor response in a subject in need thereof.

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Monrovia, CA, United States of America

Raphael Clynes