University of South Florida

The United States Government As Represented by the Department of Veterans Affairs

Raoul Salup

Mildred Enid Acevedo-Duncan

Hla Yee Win

A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-&#x3b9; and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-&#x3b9;, with respect to the control, indicates the presence of prostate cancer in the subject. The present invention is based upon the discovery that PKC-&#x3b9; levels are elevated during prostate tumorigenesis. Furthermore, the proliferation rate of the tumor correlates with the level of PKC-&#x3b9;. The invention also provides methods of treating prostate cancer by administering to the subject a compound that inhibits the expression of PKC-&#x3b9;. The compound can be a small interfering RNA (siRNA) molecule.

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Tampa, FL, United States of America

Raoul Salup