Wound Healing of Oklahoma, Inc.

Immunophotonics, Inc.

Wound Healings of Oklahoma

Raoul Carubelli

Robert E Nordquist

Wei R Chen

Joseph Raker

Peter Jenkins

Kristopher Waynant

Tomas Hode

Luciano Alleruzzo

Robert W Adams

Therapeutic compositions comprising chitosan-derived compositions are useful agents when administered in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Chitosan-derived compositions

The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.

Preparations containing glycated chitosan in a physiologically compatible carrier are described. Viscoelastic preparations comprise 1.0-12.0 percent by weight of glycated chitosan in an aqueous solution while lower viscosity solutions possess 0.1-0.5 percent by weight glycated chitosan. The otherwise free amino groups of the chitosan polymer are preferably 30-90% glycated and possess an average molecular weight of between 100,000 and 2,000,000 Daltons, and, most preferably between 100,000 and 1,000,000 Daltons.

Solutions and films of glycated chitosan

The present invention combines physical and immunologic therapies for the treatment of neoplasms by conditioning a targeted neoplasm with an immunoadjuvant (also called immuno-modulator or immunopotentiator) and then physically destroying the conditioned neoplasm. A number of physical therapies can be used to achieve the physical destruction of the conditioned tumor mass.

Combined physical and immunotherapy for cancer

A method for treating a neoplasm, such as a malignant tumor, in humans and other animals, is disclosed. A chromophore and an immunoadjuvant are introduced into the neoplasm. The neoplasm is then lased at an irradiance sufficient to induce neoplastic cellular destruction and to stimulate the self-immunological defense system against neoplastic cellular multiplication.

Laser/sensitizer assisted immunotherapy

Chitosan-derived biomaterials, and, more specifically, chitosan modified by the addition of a monosaccharide or oligosaccharide side chain to its free amino groups. The modified chitosan ('glycated chitosan') is preferably stabilized by reduction. In one particularly preferred embodiment, a galactose derivative of chitosan ('galacto-chitosan') is provided. The chitosan-derived biomaterials are useful in a myriad of biomedical applications, including as an immunoadjuvant in laser/sensitizer assisted immunotherapy.

Growing community of inventors

Oklahoma City, OK, United States of America

Raoul Carubelli