Merckle Gmbh

Raoul Bader

Hartmut Seliger

Eberhard P Hofer

Christian Rembe

Hermann Brugger

The invention relates to a device and to a process for the automatic synthesis of macromolecules on a tape-like substrate material ( ). The device has at least one synthesis module ( ) which can be sealed from the outside and comprises reaction chambers ( ) and fluid lines ( ) for filling and emptying the reaction chambers ( ) with and of reaction media, it being possible to introduce the substrate material ( ) into the synthesis module ( ) and bring it into contact with the reaction chambers ( ). Transport means ( ) which are intended to move the substrate material ( ) through a particular distance and can be actuated by a control device are furthermore provided. The invention also relates to the use of such a device for the synthesis of oligonucleotides bound on a functionalized substrate material, in particular the production of oligonucleotide libraries.

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Mainz-Laubenheim, Germany

Raoul Bader