Baxter International Inc.

Rao Chilamkurti

Clinton V Kopp

Steve Pearson

Stacey S Thompson

Mary Samuel

Norma Stephens

Jeremy C Wright

Thomas E Needham

The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (&minus;20&deg; C. or lower), or a refrigerated shelf life of up to 14 days at about 5&deg; C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.

Premixed formulation of piperacillin sodium and tazobactam sodium injection

An apparatus is provided for the safe, passive reconstruction of a drug or other beneficial agent, without requiring manual reconstitution steps. The apparatus includes a housing, preferably having a receptacle 'in-line' in an administration set and forming part of an intravenous delivery system, and a cartridge adapted for receiving a beneficial agent or beneficial agent and carrier. The cartridge is plugged into the receptacle to initiate reconstitution of the agent. The apparatus creates first and second delivery modes, in which the delivery rate of the agent to a patient is independent from and dependent upon, respectively, the fluid flow rate through the intravenous delivery system.

Drug delivery apparatus and method preventing local and systemic toxicity

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Gurnee, IL, United States of America

Rao Chilamkurti