American Cyanamid Company

Ransom B Conrow

Seymour Bernstein

John F Poletto

Gerald J Siuta

Robert Herman Lenhard

Norman Bauman

Ving J Lee

William V Curran

Vern G DeVries

David Michael Blum

Raghavan Krishnan

Jesse Gamble

A process for producing the compound [2S-(2.alpha.,3.beta.,5.alpha.)]-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-yl-m ethyl)-4-thia-1-azabicyclo[3 2 0]-heptane-2-carboxylic acid, (4-nitrophenyl)methyl ester, 4,4-dioxide, which comprises reacting a solution of azidopenamsulfone, 4-methoxyphenol and vinylpropionate with a solution of bis(trimethylsilyl)acetamide and 4-methoxyphenol is toluene at 80.degree.-100.degree. C. for 18-30 hours followed by filtering the resulting solution and cooling the filtrate to 0.degree.-10.degree. C.

Process for producing .beta.-lactamase inhibitor

Polyanionic benzene ureas and salts thereof useful as complement inhibitors.

Polyanionic benzene ureas

Multisulfonated naphthalene ureas, useful as complement inhibitors.

Multisulfonated naphthalene ureas useful as complement inhibitors

A method of inhibiting the complement system using multisulfonated naphthalene ureas.

Method of inhibiting the complement system by administering

Tetrasubstituted urea and thiourea compounds useful as antiatherosclerotic agents, compositions thereof and processes for their preparation.

Antiatherosclerotic tetrasubstituted ureas and thioureas

Ureylenebis substituted (or unsubstituted) phenylenecarbonyl (or sulfonyl)-imino-1,3,5 or 6-naphthalenetrisulfonic acids and salts thereof, useful as complement inhibitors, the intermediates thereof, and the process of making such intermediates and end products.

Ureylenebis substituted (or unsubstituted) phenylene-carbonyl (or

Naphthalenetetrayltetrakis(sulfonylimino)tetrabenzene di- and tricarboxylic acids and salts thereof useful as complement inhibitors and the process of making such compounds.

Naphthalenetetrayltetrakis(sulfonylimino)-tetrabenzene di- and

N-(4-O-.alpha.-D-glucopyranosyl-.beta.-D-glucopyranosyl)-3,4-dihydroxycinna mamide, nonakis (H-sulfate) (nonaester), nona-alkali metal or alkaline earth metal-salts, useful as modulators of the complement system, the intermediates thereof and the process of making such salts and intermediates.

Modulators of the complement system

Process for making s-phenenyltris(sulfonylimino)tri-benzene mono- and di-sulfonic acids and their salts which are useful as complement inhibitors.

Process for making s-phenenyltris(sulfonylimino)tri-benzene mono- and

Certain ureides of substituted naphthoic acids and salts useful as inhibitors of connective tissue destruction.

Substituted naphthoic acids

Naphthalenetetrayltetrakis(sulfonylimino)-aryl disulfonic acids and salts thereof useful as complement inhibitors.

Naphthalenetetrayletrakis(sulfonylimino)-aryl disulfonic acids and salts

Naphthalenetetrayltetrakis(sulfonylimino)-aryl multicarboxylic acids and salts thereof useful as complement inhibitors.

Naphthalenetetrayltetrakis(sulfonylimino)-aryl multicarboxylic acids and

s-Phenenyltris(sulfonylimino)tri-benzene mono- and di-sulfonic acids and their salts which are useful as complement inhibitors.

s-Phenenyltris(sulfonylimino)tri-benzene mono- and di-sulfonic acids and

Novel ureylenebis[substituted-phenylenecarbonyl(and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl (and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.

Growing community of inventors

Pearl River, NY, United States of America

Ransom B Conrow