Locanabio, Inc.

Locana, Inc.

Ranjan Batra

Daniela Roth

David A Nelles

Daniel A Knowland

Rachel A Adams

Eugene Yeo

Rea Lardelli Markmiller

SnRNA systems comprising engineered stem loops are disclosed herein.

Compositions and methods comprising engineered short nuclear RNA (snRNA)

Disclosed are compositions comprising: a sequence encoding a fusion protein, the sequence comprising a sequence encoding a first RNA-binding polypeptide and a sequence encoding a second RNA-binding polypeptide, wherein neither the first RNA-binding polypeptide nor the second RNA-binding polypeptide comprises a significant DNA-nuclease activity, wherein the first RNA-binding polypeptide and the second RNA-binding polypeptide are not identical, and wherein the second RNA-binding polypeptide comprises an RNA-nuclease activity. Methods of making and methods of using compositions of the disclosure are also provided. For example, compositions of the disclosure may be used in the treatment of a disease or disorder in a subject. Exemplary disease or disorders of the disclosure include genetic and epigenetic diseases or disorders.

RNA-targeting fusion protein compositions and methods for use

Growing community of inventors

San Diego, CA, United States of America

Ranjan Batra