The United States of America, As Represented by the Secretary, Department of Health and Human Services

University of Florida Research Foundation Inc

Smithsonian Institution

Ranjala Ratnayake

Hendrik Luesch

John A Beutler

Valerie J Paul

David Covell

Tanya R Johnson

The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.

Seaweed extracts, unsaturated aldehydes, and methods of treatment

Disclosed are englerins and derivatives (I) thereof useful in the treatment of a number of cancers, particularly renal cancer, as well as pharmaceutical compositions and method of treating a patient with the use of these derivatives. The englerins, for example Englerin A and Englerin B, can be isolated from the plantor produced by synthetic methods. An example of the englerin derivative is 2'-chloroenglerin A, which has the structure (II), wherein double bond 'a' is E, Z, or a mixture of E and Z. 

Epoxy-guaiane derivatives and treatment of cancer

Growing community of inventors

Gainesville, FL, United States of America

Ranjala Ratnayake