Duke University

Ranga R Krishnan

Marc G Caron

Martin Beaulieu

Tatiana D Sotnikova

Xiaodong Zhang

Raul R Gainetdinov

David A Schwartz

Redford B Williams

Raul R Gainetdinova

Lauranell Burch

A method of screening a subject for a serotonergic neurotransmission dysregulation disorder comprises detecting the presence or absence of an Tph2 mutation in the subject; and then determining that the subject is at increased risk of a serotonergic neurotransmission dysregulation disorder due to the presence or absence of the Tph2 mutation.

Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis

A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering the subject 5-hydroxytryptophan in an amount effective to enhance the activity of the serotonin enahancer, (e.g., serotonin reuptake inhibitor). In preferred embodiments the disorder is depression, anxiety, or substance abuse.

Method for augmenting the effects of serotonin reuptake inhibitors

Growing community of inventors

Chapel Hill, NC, United States of America

Ranga R Krishnan