Venatorx Pharmaceuticals, Inc.

Randy W Jackson

Christopher J Burns

Daniel C Pevear

Denis Daigle

Robert E Lee Trout

Bin Liu

Daniel McGarry

Jodie Hamrick

Steven Armen Boyd

Eugen F Mesaros

Jiangchao Yao

Allison L Zulli

Guo-Hua Chu

Matthew Lucas

Robert E Trout

Daniel Mcgarry

Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Beta-lactamase inhibitors

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Penicillin-binding protein inhibitors

Growing community of inventors

Livingston, MT, United States of America

Randy W Jackson