The Procter Gamble Company

Procter & Gamble Pharmaceuticals, Inc.

Randy Stuart Muth

Song Liu

David Edward Portlock

Paul Michael Dybas

Roland Norman Johnson

William Lee Seibel

Michael Selden Godlewski

Gilles Yves Genain

Sean Rees Klopfenstein

Jean-Jacques Koenig

Jacques De Rostolan

Sreenivasa Reddy Mundla

The present invention provides a process for making 2-amino-2-imidazoline, guanidine, and 2-amino-3,4,5,6-tetrahydroyrimidine derivatives by preparing the corresponding activated 2-thio-subsituted-2-derivative in a two-step, one-pot procedure and by further reacting yields this isolated derivative with the appropriate amine or its salts in the presence of a proton source. The present process allows for the preparation of 2-amino-2-imidazolines, quanidines, and 2-amino-3,4,5,6-tetrahydropyrimidines under reaction conditions that eliminate the need for lengthy, costly, or multiple low yielding steps, and highly toxic reactants. This process allows for improved yields and product purity and provides additional synthetic flexibility.

Process for making 2-amino-2-imidazoline, guanidine and

The present invention relates to new 14-aminosteroids, pharmaceutical compositions containing the new compounds and methods of treatment for humans or other mammals afflicted with congestive heart failure.

Oligosaccharide-containing 14 aminosteroid compounds and novel

The present invention relates to a method for making a compound of the structure: ##STR1## comprising the steps: (a) adding 6-deoxy-.alpha.-L-mannopyranosyl bromide, 2,3,4-tri-O-benzoate; DMSO; a base, selected from the group including tertiary amines, amidines, bicarbonates, carbonates, heteroaryl amine, and a solvent, hydrocarbons, esters, and ethers, in a slurry heated to 50.degree.-150.degree. C.;

Deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds

The present invention relates to oligosaccharide-containing 14-aminosteroid compounds and the pharmaceutically-acceptable acid salts or esters thereof of the general formula: ##STR1## wherein a) R.sub.1 is

Oligosaccharide-containing 14-aminosteroid compounds and novel

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Poolville, NY, United States of America

Randy Stuart Muth