Warner-lambert Company

Other

Ribozyme Pharmaceuticals, Incorporated

Warner Lambert LLC

Randy Ranjee Ramharack

Helen Tsenwhei Lee

Bruce D Roth

Drago R Sliskovic

James A McSwiggen

Dan T Stinchcomb

Roger Schofield Newton

Karen Elaine Sexton

Tomi Sawyer

John Michael Domagala

Joseph Armand Picard

Richard John Booth

Wayne Livingston Cody

Jason Keith Pontrello

Mark Allan Spahr

Amide inhibitors of microsomal triglyceride transfer protein

Diacylglycerol acyltransferase (DGAT) assay

Sulfonamide compounds and methods of treating atherosclerosis and restenosis

The present invention provides compounds having the Formula I

The present invention comprises a method of lowering plasma levels of Lp(a) in animals by administering an effective Lp(a)-reducing amount of a microsomal triglyceride transfer protein inhibitor of the structural formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is alkyl, alkenyl alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkyl, or cycloalkylalkyl, each of which is independently optionally substituted through available carbon atoms with 1, 2, or 3 groups selected from halo, alkyl, alkenyl, alkoxy, aryloxy, aryl, arylalkyl, alkylmercapto, arylmercapto, cycloalkyl, cycloalkylalkyl, heteroaryl, and heteroarylalkyl. By lowering Lp(a) levels, the animals are protected against developing premature atherosclerosis and consequent cardiovascular and cerebrovascular diseases.

Method of lowering plasma levels of lipoprotein(a)

Enzymatic RNA molecules which cleave apo(a) mRNA.

Ribozymes targeted to APO(a) RNA

Sulfhydryl containing peptides having the formula

Sulfhydryl containing peptides for treating vascular disease

Plasma levels of Lp(a) are lowered by administering an isothiazolone having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het.

Isothiazolones lower plasma levels of lipoprotein(a)

Ribozymes targeted to apo(a) mRNA

Retinoids are effective to lower plasma levels of Lp (a) in mammals.

Method for lowering plasma levels of lipoprotein (a)

Growing community of inventors

Ann Arbor, MI, United States of America

Randy Ranjee Ramharack