Pharmacia Ab

Pharmacia Corporation (of Pfizer, Inc.)

Randy J Wald

Subhash Desai

Anders Ringberg

Martin Wikberg

Torkel Gren

Sreekant R Nadkarni

Gary A DeBrincat

Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility, for example celecoxib, in an immediate-release fraction and a controlled-release, slow-release, programmed-release, timed-release, pulse-release, sustained-release or extended-release fraction. The compositions are useful in treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders.

Dual-release compositions of a cyclooxygenase-2 inhibitor

A controlled release bead comprises: (i) a core unit of a substantially water-soluble or water-swellable inert material; (ii) a first layer on the core unit of a substantially water-insoluble polymer; (iii) a second layer covering the first layer and containing an active ingredient; and (iv) a third layer of polymer on the second layer effective for controlled release of the active ingredient, wherein the first layer is adapted to control water penetration into the core. A method of producing the controlled release bead is also disclosed.

Controlled release bead, a method of producing the same and multiple unit formulation comprising it

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Portage, MI, United States of America

Randy J Wald