Bristol-Myers Squibb Compnay

Bristol-Myers Company

Randy J Koslo

Alison B Lukacsko

Joseph J Piala

Joseph Armellino

Vincent J Farina

The invention provides a safe and economical nonprescription combination of acetaminophen, aspirin and caffeine (APAP/ASA/CAF) for use in treating migraine pain and the cluster of symptoms characteristic of migraine attack, such as nausea, photophobia, phonophobia and functional disabilities. The use of the APAP/ASA/CAF combination is also effective in aborting the prodrome phase of a migraine attack.

Compositions containing the nonprescription combination of

Oral compositions containing a gastroprotective amount of zirconium aluminum glycinate, aluminum chlorohydrate or a mixture thereof are disclosed. A method for protecting the gastric mucosa against injury caused by a gastric irritant such as NSAIDs is also disclosed.

Gastroprotectant compositions and use thereof

Oral compositoins containing a gastroprotective amount of zirconium-aluminum glycinate, aluminum chlorohydrate or a mixture thereof are disclosed. A method for protecting the gastric mucosa against injury caused by a gastric irritant such as NSAIDs is also disclosed.

Complexes of sucralfate with alpha cyclodextrin, beta cyclodextrin, gamma cyclodextrin or 2-hydroxypropyl beta cyclodextrin are disclosed. Also disclosed are a process for producing complexes and compositions and a method for reducing gastric injury, employing the complexes.

Sucralfate/cyclodextrin complexes

A pharmaceutical composition and process for administering non-steroidal anti-inflammatory drugs which are protected against injury to gastrointestinal tract by beta adrenergic agonists.

Gastroprotective process

A pharmaceutical composition and process for administering non-steroidal drugs which are protected againsts injury to the gastrointestinal tract by a combination of certain H.sub.1 - and H.sub.2 -receptor blockers.

Non-steroidal anti-inflammatory compositions protected against

Processes and compositions for effecting pilomotor retraction of the hair on a hair-bearing skin area by the topical application of a .beta.-adrenergic agonist.

Processes and compositions for the topical application of

Gastroprotective process and compositions

Processes and Compositions for effecting a pilomotor effect on a hair-bearing skin area by the application of an alpha.sub.1 adrenergic agonist having essentially only alpha.sub.1 adrenergic agonist activity.

Process and composition for the topical application of alpha.sub.1

A pharmaceutical composition and process for administering non-steroidal drugs which are protected against injury to the gastrointestinal tract by a combination of certain H.sub.1 and H.sub.2 receptor blockers.

Growing community of inventors

East Windsor, NJ, United States of America

Randy J Koslo