Incyte Genomics, Inc.

Randi E Krasnow

Michael Graham Walker

Mariah R Baughn

Bridget A Warren

Tod M Klinger

Amy K Wolven

The invention provides mammalian cDNAs which encode mammalian SPARC-related proteins. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of atherosclerosis and cell proliferative disorders. The invention additionally provides expression vectors and host cells for the production of the proteins and transgenic model systems.

DNA encoding sparc-related proteins

The invention provides a mammalian cDNA which encodes a mammalian Ras association domain containing protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cell proliferative and inflammatory disorders, particularly thymus hyperplasia, allergies, asthma, and hypereosinophilia. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Ras association domain containing protein

The invention provides a cDNA which encodes a colon cancer marker. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of colon disorders, particularly colon cancer and polyps. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

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Stanford, CA, United States of America

Randi E Krasnow