Other

Case Western Reserve University

Mesoblast International Sarl

Cell Targeting, Inc.

Randell G Young

Arnold I Caplan

David Jordan Fink

Samson Tom

David J Fink

Scott Philip Bruder

Christopher Ton

Sudhakar Kadiyala

Francis Peter Barry

Lanfranco Callegaro

Luis A Solchaga

Alla Danilkovich

Robert E Newman, Jr

Josephine Mary Murphy

Giovanni Abatangelo

Zhanling Wang

Roland Moskowitz

Joseph Wagner

Jung U Yoo

One or more purified mesenchymal stem cell pharmaceutical compositions and methods of manufacture utilizing centrifugal filtration are disclosed. Threshold limits for intravenous administration of mesenchymal stem cell pharmaceutical compositions comprising residual animal products are also disclosed.

Purified mesenchymal stem cell compositions and methods of purifying mesenchymal stem cell compositions

Embodiments of the present invention are directed to a coated cell comprising a therapeutic cell and a plurality of targeting complexes coating the therapeutic cell and each of said targeting complexes comprising a homing molecule, a lipid moiety, and a spacer having from about 1 to about 10 amino acids and covalently linking the homing molecule to the lipid moiety and wherein the lipid moiety is non-covalently attached to the therapeutic cell. In some embodiments, the therapeutic cell is a stem cell. Embodiments of the invention are directed to methods of coating a therapeutic cell. Embodiments of the invention are directed to methods of treating diseases of the vasculature.

Peptide-coated cell localization to diseased or damaged tissues and methods related thereto

Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative

An implant for repair of a tissue defect which implant comprises a physiologically compatible load-bearing member having an element for securing under tension tissue adjacent to the defect to be repaired, an element for supporting a tissue reparative cell mass in the defect and a tissue reparative cell mass supported thereby. The implant can be a suture material having a cell containing matrix surrounding a central portion thereof. The matrix is preferably a gel or other material which the cells cause to contract, thereby drawing together the tissues surrounding the defect to which the implant is attached.

Biomatrix for soft tissue regeneration

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Ellicott City, MD, United States of America

Randell G Young