Medtronic, Inc.

Warsaw Orthopedic, Inc.

Randall V Sparer

Michael Eric Benz

Christopher M Hobot

Edward D DiDomenico

Mark Allan Tapsak

Maura G Donovan

David L Miller

Julie A Alkatout

David A Pearson

Andrew J Ries

Kenneth Timothy Heruth

Jeffrey Mendel Gross

Joseph F Lessar

Paul A Pignato

Mark D Breyen

Robert M Skime

Suping Lyu

Mark S Lent

Sean M Haddock

Kenneth Boone Wagener

William Jeffrey Bertrand

Darrel F Untereker

Ruchika Singhal

William L Johnson

Mark W Torrianni

Edward Di Domenico

Carlos M Duran

Anthony R Rorvick

Hong S Shim

Jesus W Casas-Bejar

William J Hooper

Brett R Vegoe

Steven G Rockow

Norma K Bullock

Brian C A Fernandes

Thomas P Grailer

Angela Pratt

John E Schwendeman

K Matthew Kinnane

Elizabeth A Ebner

Brian A Loy

Edward Didomenico

Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.

Anti-infective medical device

A process for making an implantable material comprising a composite of a biocompatible polymer and a bioactive agent. The composite combines desirable mechanical properties of polymers and the bioactivity of tissue or one or more component of tissue. More particularly, but not exclusively, the invention relates to methods for the manufacture of implantable materials, devices and components via a powder molding process.

Compression molding method for making biomaterial composites

Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.

Poly(orthoester) polymers, and methods of making and using same

An implantable medical device comprising a drug-loaded polymer overlaid with a fabric that promotes tissue ingrowth is useful in a wide variety of tissue engineering applications. The invention includes, for example, prosthetic heart valves, annuloplasty rings, and grafts, having enhanced biocompatibility and biostability. Methods of making and using the implantable medical devices of the invention are also included.

Implantable medical device with enhanced biocompatibility and biostability

Compounds that include silicon-containing groups, and optionally urethane groups, urea groups, or combinations thereof (i.e., polyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.

Compounds containing silicon-containing groups, medical devices, and methods

Compounds that include diorgano groups having quaternary carbons and optionally urethane groups, urea groups, or combinations thereof (i.e., polyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.

Compounds containing quaternary carbons, medical devices, and methods

A novel polymeric electrically insulating material that includes a linked voltage stabilizing agent. Also provided are methods of making the novel material and articles and devices that incorporate the novel material, particularly implantable medical devices.

Polymeric materials with improved dielectric breakdown strength

A high energy density capacitor comprising an organic polymeric dielectric material having a dielectric constant of at least about 7; wherein the organic polymeric dielectric material comprises polymerized alkyl (alpha-substituted)acrylate monomers having at least one dipole group; wherein when the monomers are polymerized, the dipole group is attached to the main polymeric chain through a heteroatom-containing linking group.

High energy density capacitors and compounds for use in their preparation

An implantable medical device such as a defibrillator is described. The device includes an hermetically sealed housing containing a flat electrolytic capacitor and an energy source such as a battery. The battery is connected to the capacitor and provides charge thereto. The capacitor stores the charge at a relatively high voltage. The charge stored in the capacitor is discharged through a defibrillation lead to a site on or in the heart when fibrillation of the heart is detected by the implantable medical device. Methods of making and using the implantable medical device, the capacitor, and their various components are disclosed.

Implantable medical device having flat electrolytic capacitor with connector block and sealed feedthroughs

A band-shaped annuloplasty device (e.g., C- or D-shaped ring) that is relatively rigid during handling and implantation and becomes relatively complaint after implantation. Preferably, the device includes a core material that softens after implantation.

Rigid annuloplasty device that becomes compliant after implantation

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Andover, MN, United States of America

Randall V Sparer