The Procter Gamble Company

University of Florida Research Foundation, Incorporated

Randall Stryker Matthews

Leo Timothy Laughlin, Ii

Philip Frederick Brode, Iii

Christopher Miles Miller

Garry Steven Garrett

Gary E McKibben

Daniel James Kinne

Dale Edwin Barker

Maurice E Loomans

Timothy Robert Probst

Joseph A Miller

Neil Gregory Almstead

Biswanath De

Michael G Natchus

Stanislaw Pikul

Yetunde Olabisi Taiwo

Menyan Cheng

Michael Wiard Scherz

James F Ward

Roy Lee Dobson

Garry Steven Garren

This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing

Devices and methods for eliminating termite colonies

Heterocyclic metalloprotease inhibitors

The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

The subject invention relates to compounds having the structure: ##STR1## wherein (a) x is from 1 to 5; (b) y is from 1 to 2; and (c) z is from 0 to 5. The subject invention also relates to the pharmaceutical compositions comprising the above compounds, and methods of treating inflammation using the compounds.

Sulfur containing di-tert-butylphenol compounds useful as

A compound having the structure: ##STR1## wherein (a) X is oxygen or sulfur;

Dihydrobenzothiophene compounds useful as anti-inflammatory agents

A compound having the structure: ##STR1## wherein (a) X is oxygen or sulfur; (b) each Y is independently hydrogen or unsubstituted straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms,. or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms; (c) Z is hydrogen or unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl, having from 3 to about 10 atoms other than hydrogen; (d) W is straight, branched or cyclic alkyl or aryl, unsubstituted or substituted, saturated or mono- or di-unsaturated with double bonds except that no terminal carbon atom of W is part of a double bond; W having from 1 to about 15 atoms other than hydrogen; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Dihydrobenzofuran and related compounds useful as anti-inflammatory

The present invention is directed to a process for sulfating unsaturated alcohols using inexpensive reagents and mild reaction conditions. The process comprises reacting an unsaturated alcohol of the formula R--OH, wherein R is a C.sub.8 -C.sub.22 alkenyl group, with an ether sulfate of the formula R.sup.1 (OCH.sub.2 CH.sub.2).sub.n OSO.sub.3 M, wherein R.sup.1 is a C.sub.1 -C.sub.18 hydrocarbyl group, n is an integer from 1 to 10, and M is an alkali metal, to form an unsaturated sulfate; said reaction being carried out in the presence of a catlaytically effective amount of an acid catalyst. The mole ratio of unsaturated alcohol reactant to ether sulfate ranges from about 0.5:1 to about 2:1. In this process the sulfation occurs primarily at the hydroxyl group of the unsaturated alcohol, with minimal sulfation at the olefinic moiety of said alcohol.

Process for sulfating unsaturated alcohols

The present invention involves compounds having the structure: ##STR1## (a) --A-- is selected from the group consisting of ##STR2## (b) --Y is selected from certain low molecular weight moieties which terminate in specific functional groups: --C.tbd.CH, ##STR3## and aldehydes in the form of their acetals; pharmaceutical compositions comprising such compounds; and methods for treating inflammation by administering such compounds.

Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds,

The present invention involves compounds having the structure: ##STR1## wherein: (a) --A.sup.1 is selected from the group consisting of --OH, --H, and --O.sub.2 CR;

Tert-butylphenyl compounds useful as anti-inflammatory agents

The present invention relates to novel specifically-substituted phenyl compounds, especially substituted di-tert-butyl phenol derivatives, which are effective as anti-inflammatory, analgesic and/or antipyretic agents. These phenyl compounds are substituted with a low molecular weight alkyl chain which terminates in a specific unsaturated functional group. These unsaturated functionalities are --C.tbd.CH, C.dbd.CH.sub.2, C.dbd.C.dbd.CH.sub.2, and aldehydes in the form of their acetals. The present invention further relates to pharmaceutical compositions which contain an anti-inflammatory agent of the present invention and a pharmaceutically-acceptable carrier. Finally, the present invention relates to methods for treating diseases characterized by inflammation, such as rheumatoid arthritis and osteoarthritis, in humans or lower animals. Such methods comprise administering to a human or lower animal in need of such treatment a safe and effective amount of an anti-inflammatory agent or composition of the present invention.

Novel anti-inflammatory agents, pharmaceutical compositions and methods

The 13,14-didehydro-15-oxo analogues of natural prostaglandins possess high cytoprotective activity and low diarrheogenic activity, low anti-hemostatic activity and low smooth muscle contraction activity.

Growing community of inventors

Cincinnati, OH, United States of America

Randall Stryker Matthews