Celgene Corporation

Centrexion Therapeutics Corporation

Washington University

Signal Pharmaceuticals, Inc.

Hruska, Keith

Fang, Yifu

Sloan, Victor Schorr

Randall Stevens

Peter D Hanson

Eduardo Torres

John J Sapienza

Paul E Erdman

Yoshitaka Satoh

Lida R Tehrani

Patrick Papa

Gary Fred Musso

James N Campbell

Jan Elsner

Jennifer Riggs

Garrick Kenneth Packard

Brandon Wade Whitefield

Jingjing Zhao

Veronique Plantevin-Krenitsky

Drazen Ostovic

Branden Gingsee Lee

Jayashree Tikhe

Sogole Bahmanyar

Mercedes Delgado

Andrew Antony Calabrese

William Allen Smith

Victoria Sung

Thomas A Daniel

Keith A Hruska

Sabita Sankar

Lisa Nadolny

William H Smith

Gregory D Ferguson

Yifu Fang

Kate Blease

Victor Sloan

Andrew Wallace

Douglas Hough

Victor Schorr Sloan

Rj Bates

Bruce Fahr

Patricia Rohane

Thomas Oran Daniel

Branden Lee

William Smith

Gregory Ferguson

The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

Methods and compositions for treatment of pain using capsaicin

Methods of treating, managing or preventing liver disease are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with additional active agents or treatment regimens.

Apremilast for the treatment of a liver disease or a liver function abnormality

Provided herein are methods for the treatment of bone disorders that are associated with kidney disease wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Also provided herein are methods and compositions for the treatment of low turnover bone disorders wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Further provided herein are compositions for the treatment of bone disorders that are associated with kidney disease and compositions for the treatment of low turnover bone disorders and vascular calcification.

Activin-ActRII antagonists and uses for treating bone and other disorders

Provided herein are Heteroaryl Compounds of formula (I): 

Aminotriazolopyridines, compositions thereof, and methods of treatment therewith

Growing community of inventors

Rockport, MA, United States of America

Randall Stevens