Cernofina, LLC

Cerno Biosciences, LLC

Other

USA As Represented by Secretary of the Navy

University of California

Rutgers, The State University of New Jersey

Arch Development Corporation

Randall S Alberte

Richard C Zimmerman

Robert D Smith

Phillip Crews

James S Todd

Leonard M Tender

Harold J Bright

Clare Reimers

One aspect of the present invention relates to compounds, comprising at least two moieties selected from the group consisting of aryl sulfonates and aryl sulfates. A second aspect of the present invention relates to combinatorial libraries of the aforementioned compounds. The present invention also relates to compositions comprising a compound of the present invention. A fourth aspect of the present invention relates to the use of a compound or composition of the present invention in a method for inhibiting bioadhesion to a surface. Another aspect of the present invention relates to the use of a compound or composition of the present invention in a method for enhancing bioadhesion to a surface.

Generation of combinatorial synthetic libraries and screening for novel proadhesins and nonadhesins

Generation of combinatorial synthetic libraries and screening for proadhesins and nonadhesins

Disclosed are environmentally benign crop protection compounds that interfere with the attachment of a broad range of plant pathogens to plant cells surfaces.

Environmentally benign crop protection agents

The present invention provides compounds and materials that reduce the accumulation of microorganisms a surface, by interfering with the attachment of the organisms to the surface. The compounds and materials are thus useful in preventing the formation of biofilms on surfaces in health-related environments. By preventing the formation of biofilms, the compounds formulated according to the present invention can be used in the fabrication of grafts, implants, medical devices in order to prevent infection thereof. The compounds formulated according to the present invention display an additional anticoagulant property, permitting their use in settings where decrease in blood coagulability is desirable.

Safe and effective biofilm inhibitory compounds and health-related uses thereof

A method and apparatus for generating power from voltage gradients at sediment-water interfaces or within stratified euxinic water-columns is provided. Natural voltage gradients typically exist at and about sediment-water interfaces or in isolated water bodies. One electrode (anode) is positioned in the sediment or water just below the redox boundary and the other electrode (cathode) is positioned in the water above the redox boundary over the first electrode. The anode is lower in voltage than the cathode. Current will flow when the electrodes are connected through a load, and near-perpetual generating of worthwhile power may be sustained by the net oxidation of organic matter catalyzed by microorganisms.

Method and apparatus for generating power from voltage gradients at sediment-water interfaces

The invention provides methods and compositions related to transgenic plants which incorporate genetic traits of the marine eelgrass. These traits include pathogen resistance, which may be conferred by stimulating zosteric acid biosynthesis.

Transgenic plants incorporating traits of Zostera marina

p-Sulfoxy cinnamic acid isolated from methanolic extracts of the eelgrass Zostera marina having significant antifouling aquatic properties. p-Sulfoxy cinnamic acid was synthesized in the laboratory from p-coumaric acid, and antifouling activity was identical to the natural compound in laboratory bioassays. In addition, sulfate esters of other phenolic acids showed similar antifouling activity, suggesting that the sulfate ester was responsible for the antifouling effect.

Phenolic acid sulfate esters for prevention of marine biofouling

p-sulfoxy cinnamic acid isolated from methanolic extracts of the eelgrass Zostera marina having significant antifouling aquatic properties. p-sulfoxy cinnamic acid was synthesized in the laboratory from p-coumaric acid, and antifouling activity was identical to the natural compound in laboratory bioassays. In addition, sulfate esters of other phenolic acids showed similar antifouling activity, suggesting that the sulfate ester was responsible for the antifouling effect.

Growing community of inventors

Falmouth, ME, United States of America

Randall S Alberte