Schering Corporation

Pharmacopeia Inc.

Adriano Afonso

John J. Baldwin

Ge Li

Randall R. Rossman

Dinanath F. Rane

Alan K. Mallams

John C. Reader

Ronald J. Doll

F. George Njoroge

Randall R Rossman

Alan K Mallams

Ronald J Doll

F George Njoroge

Dinanath F Rane

John J Baldwin

John C Reader

Viyyoor Moopil Girijavallabhan

Ashit K Ganguly

Olga Sarre

George F Njoroge

Dinanth F Rane

Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

Tricyclic compounds

Novel carbonyl piperazinyl and piperidinyl compounds and pharmaceutical compositions are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel carbonyl piperazinyl or piperidinyl compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

Carbonyl piperazinyl and piperidinyl compounds

Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

Tricyclic compounds useful for inhibition of G-protein function and for

Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the Formula 1.0 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

3-O-Glycosyl derivatives of 16-membered macrolides such as O-.alpha.-L-cladinosyl-(1.fwdarw.3)-12,13-dehydro-12,13-deoxorosaramicin, 2', 4',4''-tri-O-acetyl-O-(4'-O-phenoxyacetyl-.alpha.-L-cladinosyl)-(1.fwdarw. 3)-desmyconsin and pharmaceutically acceptable acid addition salts thereof useful as antibacterials are disclosed.

3-O-glycosyl 16-membered macrolide antibacterials and related derivatives

There are disclosed novel di- and tri-O-acetyl-23-O-demycinosyl-4'-O-iso-valeryltylosins and the pharmaceutically acceptable salts thereof, which have improved activity as antibacterials and provide higher blood levels than other tylosin derived compounds. These compounds have the following structural formula ##STR1## wherein R is acetyl or hydrogen and z is for example O or ##STR2##

Di and tri-O-acetyl-'O-iso-valeryl-23-O-demycinosyl tylosins, hydrazone

12,13-Oxo derivatives of 16-membered macrolides such as tylosin and 23-O-demycinosyltylosin useful as antibacterials are disclosed.

12,13-oxoderivatives of macrolides

Growing community of inventors

Nutley, NJ, United States of America

Randall R Rossman