Smithkline Beecham Corporation

Smithkline Beckman Corporation

Randall K Johnson

David T Hill

Christopher K Mirabelli

William D Kingsbury

David A Berges

Sidney M Hecht

Jeffrey Charles Boehm

Robert Philip Hertzberg

Yen Sen Ho

Peter J Sadler

Kenneth G Holden

Susan J Berners-Price

The present invention relates generally to compositions comprising potentiators, such as IL-18, also known as interferon-&ggr;-inducing factor (IGIF), in combination with a chemotherapeutic agent, processes for making such compositions, the use of such compositions for the prevention and/or treatment of cancer, and the use of such compositions to inhibit the growth of tumors or cancerous cells in mammals.

IL-18/IGIF chemotherapeutic compositions

Uridine kinase polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing uridine kinase polypeptides and polynucleotides in diagnostic assays.

Human uridine kinase

The present invention provides a method of treating viral infections by using antiviral substituted indolizino�1,2-b!quinolinone compounds, antiviral substituted indolizino�1,2-b!quinolinone compounds, and pharmaceutical compositions thereof.

Substituted indolizino�1,2-b!quinolinones

A method of treating non-small cell lung carcinoma in a human afflicted therewith which comprises administering to such human an effective amount of a compound of the water soluble camptothecin analog class.

Treatment of non-small cell lung carcinoma

A method of treating ovarian cancer in a human afflicted therewith which comprises administering to such human an effective amount of a compound of the water soluble camptothecin analog class.

Treatment of ovarian cancer

Invented is a Method of Treating Prostatic Adenocarcinoma by employing asteroid 5-.alpha.-reductase inhibiting compound or a combination of steroid 5-.alpha.-reductase inhibiting compounds.

Method of treating prostatic adenocarcinoma

A pharmaceutical composition comprising a compound of the camptothecin analog class and a platinum coordination compound and a pharmaceutically acceptable carrier or diluent; a method of inhibiting the growth of tumor cells in a human afflicted therewith which comprises administering to such human an effective tumor cell growth inhibiting amount of such pharmaceutical composition; and a method of inhibiting the growth of tumor cells in a human afflicated therewith which comprises administering to such human an effective tumor cell growth inhibiting amount of the combination of a compound of the camptothecin analog class and a platinum coordination compound.

Combination chemotherapy

Invented is a Method of Treating Prostatic Adenocarcinoma by employing a steroid 5-.alpha.-reductase inhibiting compound or a combination of steroid 5-.alpha.-reductase inhibiting compounds.

Pharmaceutical compositions and a method for inhibiting the growth of tumor cells by administering a tumor cell growth-inhibiting amount of a bis[bis (diphenylphosphino)hydrocarbon]-, bis[bis(diethylphsophino) hydrocarbon]-, bis[bis(diphenylphosphine-deithylphosphino) hydrocarbon]gold(I), silver(I) or copper(I) complex or a tris[bis(diphenylphosphino)ethane] dicopper(I) complex to an animal afflicted with said tumor cells.

Tumor cell growth-inhibiting pharmaceutical compositions containing

Water soluble camptothecin analogs, pharmaceutical compositions comprising such analogs, and a method of inhibiting the growth of tumor cells sensitive to such analogs in an animal in need thereof.

Water soluble camptothecin analogs useful for inhibiting the growth of

2-pyridyl and 4-pyridyl phosphine gold compounds of the formula: ##STR1## and 2-pyridyl phosphine gold compounds of the formula: ##STR2## and pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound.

'2-pyridyl and 4-pyridyl phosphine gold (I) anti tumor complexes'

Compounds, pharmaceutical compositions and a method for treating tumors by administering an effective tumor cell growth-inhibiting amount of a .alpha.,.omega.-bis(disubstitutedphosphino)hydrocarbon compound or a [.alpha.,.omega.-bis(disubstitutedphosphino)hydrocarbon] digold(I), digold(III, disiliver(I) or dicopper(I) complex to an animal afflicted by such tumor cells.

Antitumor compounds

Antitumor pharmaceutical compositions and methods for treating tumors employing .alpha.,.omega.-bis(disubstitutedphosphino)hydrocarbon derivatives or [.alpha.,.omega.-bis(disubstituted phosphino)hydrocarbon] digold(I), digold(III), disilver(I), and dicopper(I) derivatives are disclosed.

Antitumor pharmaceutical compositions and methods for treating tumors

Pharmaceutical compositions containing an effective, tumor cell growth-inhibiting amount of such a compound, and a method for treating tumor cells sensitive to such a di-gold phosphine compound which comprises administering a tumor cell growth-inhibiting amount of such a compound to an animal afflicted by said tumor cells.

Growing community of inventors

Ardmore, PA, United States of America

Randall K Johnson