Scikon Innovation, Inc.

The University of North Carolina at Chapel Hill

Randall Edwin McClelland

Maureen Kay Bunger

Lola M Reid

Frank Jay Ziberna

Eliane Wauthier

Hsin-Lei Yao

David J Sloan

Timothy C Jensen

Joshua Uronis

Disclosed are fluidics devices and assemblies allowing for fluid flow between a plurality of wells. The fluidics devices and assemblies that are provided mimic in vivo tissue environments by allowing for initially segregated tissue cultures that can then be linked through fluid flow to measure integrated tissue response. The fluidics devices and assemblies provide a pumpless system using surface tension, gravity, and channel geometries. By linking human tissue functional systems to better simulate in vivo feedback and response signals between the tissues, the need for testing in animals can be minimized. Further, piston assemblies and related systems are provided for nesting engagement on top of the fluidics device in order to provide a dosing fluid thereto.

Piston assembly and related systems for use with a fluidics device

Disclosed are fluidics devices and assemblies allowing for fluid flow between a plurality of wells. The fluidics devices and assemblies that are provided mimic in vivo tissue environments by allowing for initially segregated tissue cultures that can then be linked through fluid flow to measure integrated tissue response. The fluidics devices and assemblies provide a pumpless system using surface tension, gravity, and channel geometries. By linking human tissue functional systems to better simulate in vivo feedback and response signals between the tissues, the need for testing in animals can be minimized.

Method and related systems for use with a fluidics device

Disclosed are fluidics devices and assemblies allowing for fluid flow between a plurality of wells. The fluidics devices and assemblies that are provided mimic in vivo tissue environments by allowing for initially segregated tissue cultures that can then be linked through fluid flow to measure integrated tissue response. The devices and assemblies provide a pumpless system using surface tension, gravity, and channel geometries. By linking human tissue functional systems to better simulate in vivo feedback and response signals between the tissues, the need for testing in animals can be minimized.

Fluidics device allowing fluid flow between a plurality of wells

Assay tray assembly

A method is provided for controlling the survival, proliferation, and/or differentiation of hepatic progenitors in vitro by using specific types of mesenchymal feeder cells or one of more of the paracrine signals produced by those feeders.

Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same

Growing community of inventors

Chapel Hill, NC, United States of America

Randall Edwin McClelland