Clexio Biosciences Ltd.

Cima Labs Inc.

Randal A Seburg

Derek V Moe

Victoria Ann O'Neill

Manuel A Vega Zepeda

Dinesh K Haswani

Sagar Rane

Disclosed herein are immediate release oral dosage forms that contain abuse-deterrent and abuse-resistant features. In particular, the disclosed dosage forms can provide deterrence of abuse by ingestion of multiple individual doses. The disclosed dosage forms can likewise provide protection from overdose in the event of accidental or intentional ingestion of multiple individual doses. The dosage forms may also exhibit abuse resistant properties when physically manipulated, and also when physically manipulated and then administered in a manner not consistent with oral dosing. The dosage forms may also exhibit abuse resistant properties when administered in a manner intended to result in administration of the esketamine in a higher than therapeutic dose.

Abuse-deterrent dosage forms containing esketamine

Described are immediate release oral dosage forms that contain abuse-deterrent features. In particular, the disclosed dosage forms provide deterrence of abuse by ingestion of multiple individual doses. In addition, the disclosed dosage forms provide protection from overdose in the event of accidental or intentional ingestion of multiple individual doses.

Immediate release abuse-deterrent granulated dosage forms

Growing community of inventors

Maple Grove, MN, United States of America

Randal A Seburg