Ottawa Heart Institute Research Corporation

Jubilant Draximage Inc.

Ran Klein

Etienne Lefort

Robert A Dekemp

Vincenzo Teoli

Robert A deKemp

Vicenzo Teoli

ÉTienne Lefort

Embodiments of the present invention provide for assessing the state of anRb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration ofRb,Sr, orSr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, aSr/Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of theRb elution system.

Rubidium elution system control

A method of controlling anSr/Rb elution system having a generator valve for proportioning a flow of saline solution between anSr/Rb generator and a bypass line coupled to an outlet of the generator such that saline solution traversing the bypass line will merge with eluted saline solution emerging from the generator to provide an active saline solution. During each elution run, a plurality of successive concentration parameter values are obtained at predetermined intervals. Each concentration parameter value is indicative of a respective instantaneous activity concentration of the active saline solution. Respective error values between each concentration parameter value and a target activity concentration value of the elution run are computed. Error data based on a plurality of the computed error values is accumulated. Between successive elution runs, at least one performance parameter of the elution system is adjusted based on the accumulated error data.

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Ran Klein