Precigen, Inc.

Ramya Yarlagadda

Rutul R Shah

Peter Emtage

Cheryl G Bolinger

Simon Metenou

Vinodhbabu Kurella

Kuan-Fu Ding

Douglas E Brough

Prabakaran Ponraj

Tim Chan

Provided herein are engineered human papilloma virus (HPV) molecular vaccine constructs. Vaccine constructs can also include ligand-inducible engineered gene switch systems for modulating expression of heterologous genes, such as a cytokines, in host cells.

Human papillomavirus vaccines and uses of the same

Provided herein are engineered hepatitis B virus (HBV) molecular vaccine constructs. Vaccine constructs can also include ligand-inducible engineered gene switch systems for modulating expression of heterologous genes, such as a cytokines, in host cells.

Hepatitis B vaccines and uses of the same

Disclosed herein are polynucleotides encoding cell tags for use in immunotherapeutic applications, and systems comprising polynucleotide cell tags for regulating the activity of a cell. The compositions, methods and systems described herein provide tools for regulating activity of genetically engineered cells in a subject.

Expression of novel cell tags

Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from a CD33 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders such as acute myeloid leukemia (AML), and relapsed or refractory AML.

Growing community of inventors

Gaithersburg, MD, United States of America

Ramya Yarlagadda