Ipca Laboratories Limited

Ramsingh Gajendrasingh Thakur

Ashok Kumar

Dharmendra Singh

Navinchandra Darpan Pandya

Shankar Deepak Panmand

Atul Jadhav

A one-pot industrial process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazole-1-yl)methyl]-4H-carbazol-4-one of Formula-(I) from 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one of Formula-(IV) involves reaction of Formula (IV) with HNRRsalt and paraformaldehyde, where R,Rare independently alkyl groups or together forms a cyclic alkyl group, in a solvent system of acetic acid and hydrocarbon solvent to form a crude mixture of intermediate compounds of Formula (III) and (VIII), which is converted to ondansetron (Formula (I)) without isolation by reaction with 2methyimidazole in a suitable solvent system in the same pot.

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Maharashtra, India

Ramsingh Gajendrasingh Thakur