Genentech, Inc.

University of California

Xenon Pharmaceuticals Inc.

Ramsay Beveridge

Liang Zhao

Paul Gibbons

Kwong Wah Lai

Marie-Gabrielle Braun

Steven McKerrall

Joachim Rudolph

Jean-Philippe Leclerc

Alexandre Lemire

Bing-Yan Zhu

Daniel P Sutherlin

Jacob Bradley Schwarz

Wendy Lee

Georgette M Castanedo

Claudio F Sturino

Vishal Verma

Jason R Zbieg

Cuong Q Ly

Philippe Bergeron

Marie Anne Evangelista

Paul Powell Beroza

Lisa Marie Barton

Bryan Ka Ip Chan

Samir Bouayad-Gervais

Russell Tyler Smith

Anwesha Dey

Leo Fu

Avi J Ashkenazi

Fei Wang

Birong Zhang

Nicole Blaquiere

Michael Scott Wilson

Guosheng Wu

Zhiguo Liu

Wenfeng Liu

Yao Wu

Tommy Lai

Curtis Colwell

Melissa Leblanc

William Vernier

Nicole Alice Blaquiere

Described herein are pyrido-pyrimidinone and pteridinone compounds or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods treating cancer, alone and in combination with other therapeutic agents.

Pyrido-pyrimidinone and pteridinone compounds and methods of use

This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

Therapeutic compounds and methods of use

The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables Y-Y, X, Z, Z, Z, R-R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. The compounds have sodium channel blocking activity that are useful for treating sodium channel-mediated diseases, in particular for treating pain.

Pyridine-sulfonamide derivatives as sodium channel inhibitors

Pyrazolo compounds and methods of use thereof

Described herein are phenoxy-pyridyl-pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Phenoxy-pyridyl-pyrimidine compounds and methods of use

The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative: 

Therapeutic compounds and methods of use thereof

Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I or I' structure: 

Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating IRE1-related diseases and disorders

The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y&#x2014;Y, R, R, R, R, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

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Montreal, Canada

Ramsay Beveridge