Columbia University

Icahn School of Medicine at Mount Sinai

Ramon Parsons

Jian Jin

Xiaobao Yang

Ilias Stratikopoulos

Anqi Ma

Jing Liu

Rodney J Rothstein

Xufen Yu

Jacquelyn Shaw

John Dittmar

Xing Du

Jia Xu

Robert J D Reid

Matthew Maurer

Methods for designing bivalent compounds which selectively degrade/disrupt EZH2 and compositions and methods of using such degraders/disruptors to treat EZH2-mediated cancer are provided.

Compositions and methods for treating EZH2-mediated cancer

Disclosed herein are serine threonine kinase (AKT) degradation/disruption compounds including an AKT ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of AKT-mediated diseases.

Serine threonine kinase (AKT) degradation / disruption compounds and methods of use

Methods to treat certain types of cancer with cyclophilin inhibitors.

Methods to treat cancer using cyclosporine and cyclosporine derivatives

A composition for delivering cargo molecules across biological membranes is provided comprising (i) a peptide comprising consecutive amino acid residues having the sequence set forth in SEQ ID NO 1 for the transport of a cargo molecule across a biological membrane and (ii) the cargo molecule, wherein the cargo molecule is not a peptide comprising amino acid residues having the sequence set forth in SEQ ID NO 4. Methods of delivering cargo molecules across biological membranes are also provided. Methods of treating a tumor, cancer, a metabolic disorder, and a cardiovascular disorder are also provided.

[object Object]

An isolated human phosphatase and tensin homolog long polypeptide (PTEN-long) comprising SEQ ID NO:1, fragments and analogs thereof, nucleic acids encoding such and compositions comprising such are provided. Methods to inhibit angiogenesis in a solid tumor, treat a solid tumor, and inhibit growth of a solid tumor using PTEN-long, fragments and analogs thereof, are provided.

Identification of extracellular form of PTEN that can be used to treat tumors

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Manhasset, NY, United States of America

Ramon Parsons