Best Medical International, Inc.

Ramiro Pino

Paul S Nizin

Feng Ma

Merle Romesberg, Iii

A system to provide enhanced computational efficiency in a simulation of particle transport through a medium, program product, and related methods are provided. The system can include a simulation data administrator server having access to an interaction database including records related to parameters describing interactions of particles in an absorbing medium to provide particle interaction parameters, and a simulated dose calculation computer in communication with the simulation data administrator server through a communications network. The system can also included simulated dose calculation program product stored in memory of the simulated dose calculation computer and including instructions that when executed by a processor causes the processor to perform for each of a plurality of particles deliverable from a particle source the operations of providing parameters for a medium to perform a Monte Carlo simulation to develop a map of simulated absorbed dose in the medium, and artificially adjusting simulation particle fluxes to achieve a substantially constant variance throughout a depth of the medium.

Variance reduction simulation system, program product, and related methods

A system to provide enhanced computational efficiency in determining dose in a media of varying density from a high-energy radiation-beam for radiation treatment, program product, and related methods are provided. The system can include a radiation treatment planning computer and radiation treatment planning program product adapted to enhance optimization of a radiation treatment plan for delivering radiation to a complex medium defining a patient volume. The program product provides functions including those for predetermining a delivery machine-dependent representation of radiation dose for different electron densities selected over a representative range, predetermining a depth-dependent representation of central axis properties of a pencil beam passing through a complex medium, and determining with constant time computational complexity, radiation dose for each of a plurality of points of interest in a heterogeneous medium having a complex spatial distribution of heterogeneous electron densities by applying the predetermined machine-dependent and depth-dependent representations.

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Pearland, TX, United States of America

Ramiro Pino