The United States of America, as Represented by the Secretary, Department of Health and Human Services

Ramiro Iglesias-Bartolome

James B Mitchell

J Silvio Gutkind

Alfredo Molinolo

Vyomesh Patel

Ana P Cotrim

Disclosed is a method of preventing the development of mucositis in a subject undergoing radiation therapy or chemotherapy for a disease in need thereof comprising administering an effective amount of a mammalian target of rapamycin (mTOR) inhibitor, such as rapamycin, to the subject. Further disclosed is a method of increasing the lifespan of a normal oral keratinocyte and/or reducing oxidative stress in a normal epithelial cell, wherein the method comprises administering an effective amount of an mTOR inhibitor to a subject undergoing radiation therapy or chemotherapy for a disease in need thereof.

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Bethesda, MD, United States of America

Ramiro Iglesias-Bartolome