Mayo Foundation for Medical Education and Research

Ramesh K Ramanathan

Mitesh J Borad

Michael T Barrett

Barbara A Pockaj

Karen S Anderson

This document provides methods and materials involved in assessing cancer (e.g., breast cancer). For example, methods and materials for determining whether or not a cancer patient (e.g., a breast cancer patient) having ER&#x2212;/PgR&#x2212;/HER2&#x2212; cancer cells is likely to have a favorable or unfavorable outcome and/or is likely to respond a cancer treatment that includes a PD-1 inhibitor and/or PD-L1 inhibitor in combination with a JAK2 inhibitor are provided. Methods and materials involved in treating mammals having ER&#x2212;/PgR&#x2212;/HER2&#x2212; cancer (e.g., ER&#x2212;/PgR&#x2212;/HER2&#x2212; breast cancer) by administering a PD-1 inhibitor and/or PD-L1 inhibitor in combination with a JAK2 inhibitor also are provided.

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Paradise Valley, AZ, United States of America

Ramesh K Ramanathan