Hoechst Aktiengesellschaft

Ramesh Gidwani

Hans-Jochen Lang

Wolfgang Scholz

Heinrich Christian Englert

Bansi Lal

Ramanujam Rajagopalan

Radha Panicker

Chinnakulandai Sankar

Described are guanidinocarbonyl isoquinolines of the formula I, ##STR1## wherein R(1) is hydrogen, (amino) (cyclo) (aryl)alk(en)yl (heteroaryl); R(2) is hydrogen, halogen, alkyl, or aryl; G is a radical of the formula VII: ##STR2## X(2), X(3) and X(4) are hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono) (di) (lower alkyl) (amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also a process for their preparation, their use as medicaments, and medicaments containing them for treating congestive heart failure, and arrhythmic conditions as well as cardioprotective agents in mammals.

Antiarrhythmic and cardioprotective substituted -1(2H)isoquinolines,

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Bombay, India

Ramesh Gidwani