Rohm and Haas Company

Ramesh B Petigara

Barry C Lange

Horst O Bayer

Edward S Lashen

Ethan S Simon

John R Mattox

George H Redlich

Kevin F Gironda

Norman A Leister

Robert A Woodruff

Barry J Pendell

Douglas N Sharp

Stable microbicidal compositions containing a 3-isothiazolone compound, metal nitrate, bromic acid, iodic acid, periodic acid, or their salts and water are disclosed. Also disclosed are methods of preventing or reducing precipitate formation in 3-isothiazolone compositions.

Stable microbicide formulation

The present invention provides an improved method of stabilizing of 3-isothiazolone solutions using bromate compounds by buffering the pH of the solution in the range of 4 to 5.1, and compositions which comprise 3-isothiazolone compound, bromate compound stabilizer, and sufficient buffer to maintain the pH in said range.

Bromate stabilization of nitrate-free 3-isothiazolones at pH 4-5.1

Process for producing substantially separated 5-chloro-2-methyl-3-isothiazolone (CMI) and 2-methyl-3-isothiazolone (MI) from a mixture of their hydrochloride salts, or in a special mixture having a higher ratio of CMI to MI, comprising heating a mixture of CMI.HCl and MI.HCl for a period of time necessary to fully dissociate said CMI.HCl and form substantially pure CMI, but insufficient to fully dissociate said MI.HCl.

3-isothiazolone biocide process

Nitrosamine-free 3-isothiazolone biocidal compositions suitable for applications where substantial human or animal contact is anticipated, their method of use and process of preparation are disclosed.

Nitrosamine-free 3-isothiazolones and process

Nitrosamine-free-3-isothiazolones and process

Bromate stabilizers for 3-isothiazolones

An improved process for preparing a 3-isothiazolone of the formula ##STR1## wherein R and R.sup.1 are independently selected from hydrogen, halogen or R is a (C.sub.1 -C.sub.4) alkyl group and R.sup.1 is a halogen; Y is hydrogen, a (C.sub.1 -C.sub.18) alkyl group, an unsubstituted or halo-substituted (C.sub.2 -C.sub.8) alkenyl or alkynyl, a cycloalkyl or substituted (C.sub.3 -C.sub.12) cycloalkyl, an aralkyl or halo-, (C.sub.1 -C.sub.4) alkyl-, or (C.sub.1 -C.sub.4) alkoxy-substituted aralkyl of to 10 carbon atoms, or an aryl or halo-, (C.sub.1 -C.sub.4) alkyl-, or (C.sub.1 -C.sub.4) alkoxy-substituted aryl aryl group of up to 10 carbon atoms; comprising

Bromate as inhibitor of nitrosamine formation for nitrate stabilized

Process for nitrosamine-free sabilized isothiazolones

A process for preparing a 3-isothiazolone of the formula ##STR1## wherein Y is selected from the group consisting of alkyl or substituted alkyl of 1 to 10 carbon atoms; unsubstituted or halogen-substituted alkenyl or alkynyl of 2 to 10 carbon atoms; and aralkyl or halogen-, lower alkyl-, or lower alkoxy-substituted aralkyl of up to 10 carbon atoms;

Process for the preparation of salt free, water free 3-isothiazolone

A process for obtaining pure 2-substituted-3(2H)-isothiazolones is presented, wherein the substituent is alkyl, linear or branched. By developing suitable conditions, the isothiazolone hydrochloride is isolated from the complex reaction media wherein it is formed as readily filterable crystals of high purity. Such purified crystals are then utilized in isolation of isothiazolone of high purity.

Purification of isothiazolones

Nitrosamine-free 3-isothiazolone

Disclosed novel substituted 3-isothiazolones, salts thereof, metal complexes thereof, their preparation, agricultural compositions containing them, and their utilization in the control of living organisms. In particular, novel 5-(substituted thiocarbamoyl)thio-2-substituted-4-isothiazolin-3-ones and related compounds including 5-piperidino and 5-cyano derivatives are disclosed.

Growing community of inventors

Hatfield, PA, United States of America

Ramesh B Petigara