Council of Scientific and Industrial Research

Reliance Industries Limited

Ramesh Anna Joshi

Rohini Ramesh Joshi

Mukund Keshav Gurjar

Muthukrishnan Murugan

Sanjay Pandurang Borikar

Uttam Ramrao Kalkote

Sanjay Narayan Nene

Vithal Venkatrao Jogdand

Digambar Vitthal Gokhale

Kulbhushan Balwant Bastawde

Bhaskar Ganapatrao Gaikwad

Thottapillil Ravindranathan

Dinesh Ramesh Garud

Shamrao Ganapatrao Patil

Virendrakumar Gupta

Amol Arvind Kulkarni

Asmita Ashutosh Prabhune

Hiren Manojkumar Bhajiwala

Ravindranathan Thottappillil

Amarjyoti Kalita

Sunil Dhamaniya

Nilesh B Karade

Dinesh Rämesh Garud

M K Gurjar

Anna R Joshi

Arvind A Kulkarni

Nayana Tushar Nivangune

Manisha Abdhiman Jagtap

The Zigler-Natta catalyst composition of the present disclosure provides uniform polyethylene having a molecular weight in the range from 1 million g/mol to 12 million g/mol. The Zigler-Natta catalyst composition of the present disclosure comprises external electron donor selected from the group consisting of substituted silanediyl diacetate, trialkyl borate and tetraalkoxysilane.

Ziegler-Natta catalyst composition for preparing polyethylene

Beta aminocrotonates are important intermediates for the synthesis of Ca channel blockers. The processes available in the art are batch processes with yields about 85%. There are no continuous processes available for the synthesis of such compounds. This gap in the art is addressed by the invention by disclosing a continuous process resulting in high yields of beta amino crotonates.

Process for continous flow synthesis of beta-amino crotonate

Disclosed herein is a continuous tubular reactor based conversion of acetophenones to amino substituted acetophenones wherein the nitration is carried out at &#x2212;10 to 10&#xb0; C. followed by reduction to m-nitrophenone resulting in uniform output of product, said process comprising the steps of: a) Nitrating acetophenone with nitrating agent (nitration mixture or fuming nitric acid) at &#x2212;10 to 10&#xb0; C.; b) Isolating m-nitro acetophenone from a mixture of o and m-nitro acetophenone and c) Reducing the m-nitro to obtain m-amino acetophenone.

Continuous two step flow synthesis of M-amino acetophenone

The present invention relates to RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol of the formula (1), process for preparation thereof by selective allylation of p-hydroxy phenyl ethanol and use thereof in a preparation of RS betaxolol of formula (2) 

RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol, process for preparation thereof and process for preparation of RS betaxolol

The present invention relates to a process for the preparation of [S(&#x2212;) amlodipine-L(+)-hemi taratarte] from RS amlodipine base using L(+) tartaric acid in the presence of dimethyl sulfoxide.

Process for the preparation of S(&#x2212;) amlodipine-L(+)-hemi taratarte

The present invention relates to an improved process for preparation of S-(&#x2212;)-betaxolol salts. More particularly the present invention relates to the preparation of hydrochloride salt of S-(&#x2212;)-betaxolol of formula (1)

Process for preparation of S-(-)-betaxolol and salts thereof

The present invention relates to a novel compound S-(&#x2212;)-1-{4-[2-(allyloxy)-ethyl] phenoxy}-3-isopropylamino propan-2-ol of formula 1 and to a process for the preparation thereof. More particularly the present invention relates to a process for preparing S-(&#x2212;)-1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol of formula 1 by selective allylation of p-hydroxy phenyl ethanol. The present invention also relates to a process for conversion thereof to S-(&#x2212;)-betaxolol of formula 2

S-(&#x2212;)-1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol, process for preparation thereof and process for preparation of S-(&#x2212;)betaxolo

A process for the preparation of pharmaceutically acceptable salts of chiral Amlodipine namely S(&#x2212;) Amlodipine and R(+) Amlodipine from without isolation of a free base from with optical purity rank between 96-99% is described in the present invention. The process comprises resolving RS amlodipine base using of L(+) or D(&#x2212;) tartaric acid to obtain salt of corresponding to the acid used in ee rang from 96-99%.

Process for preparation of chiral amlodipine salts

The present invention provides a process for preparation of optically active azabicyclo heptanone derivates using lactamases that will react with racemic lactam of formula (I) to give a single enanotiomer of lactam (III) and the corresponding ring opened compound of formula (IV) in an enantiomerically pure form.

Process for the preparation of optically active azabicyclo heptanone derivatives

A process for the preparation of S(&minus;) Amlodipine salts which comprises reaction of S(&minus;)Amlodipine base with a solution of pharmaceutically acceptable acid such as benzene sulfonic acid, oxalic acid, maleic acid, succinic acid and p-toluene sulfonic acid. The reaction is carried out in the presence of an organic solvent at room temperature. The organic solvents include alcohols like ethanol methanol 2 propanol hydrocarbons like toluene and polar solvent like dimethyl sulfoxide. The salt is obtained by addition of water and isolation of the salt formed by filtration. The unique feature of the invention is production of S(&minus;) Amlodipine besylate in good chemical yield, high enantiomeric purity and with the quality required for preparation of pharmaceutical composition i.e. tablet formulation.

Process for making S(-) Amlodipine salts

The present invention provides a method to prepare alkyl-4-&lsqb;2(phthalimido)-ethoxy&rsqb;-acetoacetate which are useful in the manufacture of anti-hypertensive and anti-ischaemic drugs by reacting 2(phthalimido)-ethoxyacetic acid with thionyl chloride and then reacting the acid chloride product obtained with Meldrums acid.

Process for the preparation of alkyl 4&lsqb;2-(phthalimido)ethoxy&rsqb;-acetoacetate

A microbial process for the preparation of D(-)-N-carbamoylphenylglycine from DL-5-phenylhydantoin which comprises culturing the strain pseudomonas sp. having Accession No. NCIM 5070 (ATCC 55940) and deposited in National Collection of Industrial Microorganisms (NCIM), National Chemical Laboratory (NCL) (India), having hydantoinase activity, in a medium for 16-20 hours, separating the cells by centrifugation, treating the solid cells obtained with DL-5-phenylhydantoin in buffer, at a temperature in the range of about 25-30&deg; C. for a period of about 2-6 hours, acidifying the mixture to obtain solid D(-)-N-carbamoylphenylglycine, and separating the product by filtration.

Microbial process for the production of D(-)-N-carbamoylphenylglycine

A microbial process for the preparation of D(-)-N-carbamoylphenylglycine from DL-5-phenylhydantoin which comprises culturing the strain pseudomonas sp. having Accession No. NCIM 5070 (ATCC 55940) and deposited in National Collection of Industrial microorganisms (NCIM), National Chemical laboratory (NCL) (India), having hydantoinase activity, in a medium for 16-20 hours, separating the cells by centrifugation, treating the solid cells obtained with DL-5-phenylhydantoin in buffer, at a temperature in the range of about 25-30.degree. C. for a period of about 2-6 hours, acidifying the mixture to obtain solid D(-)-N-carbamoylphenylglycine, and separating the product by filtration.

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Maharashtra, India

Ramesh Anna Joshi