Idexx Laboratories, Inc.

Ramaswamy Chandrashekar

Melissa Jane Beall

Thomas Patrick O'Connor, Jr

Jiayou Liu

Eugene Regis Krah, Iii

Phyllis Ione Tyrrell

Thomas P O'Connor

Katherine Jean Esty

Eugene Regis Krah

Thomas Patrick O'connor

Melissa Beall

The invention providesantigens that can be used to detectinfected animals regardless of whether the animals have been vaccinated for. The invention also provides compositions and methods for determining the presence ofantigens and antibodies.

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The invention provides methods and compositions for the detection and treatment ofandinfection.

The invention provides compositions and methods for the detection ofpolynucleotides and polypeptides.

The invention provides compositions and methods for the detection and quantification of(formerly known as) antibodies and antibody fragments.

A method and device for determining whether an animal is infected with West Nile Virus (WNV), or is either not infected or vaccinated with a WNV vaccine. The method includes contacting a biological sample from the subject with a first WNV polypeptide that is not an element of the WNV vaccine, and detecting whether antibodies in the sample bind to the WNV polypeptide. If the antibodies in the sample bind to the WNV polypeptide, it can be determined that the animal is naturally infected with WNV and if the antibodies do not bind to the polypeptide, it can be determined that the animal is either vaccinated or not infected.

Detection of West Nile virus infection and vaccination

A method and device for detecting a West Nile Virus (WNV) infection including contacting a biological sample from a subject with an anti-IgM antibody and a recombinant WNV E polypeptide and detecting whether the polypeptide substantially binds to an antibody in the sample. The invention also includes a method and device for determining whether an animal is infected with West Nile Virus (WNV), or is either not infected or is vaccinated with a WNV vaccine.

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Scarborough, ME, United States of America

Ramaswamy Chandrashekar