Zoetis LLC

Pfizer Corporation

Ah USA 42 LLC

Ramasamy M Mannan

Paul Joseph Dominowski

Richard Lee Krebs

Pamela K Klose

James Richard Thompson

Risini Dhammika Weeratna

Cedo Martin Bagi

Shucheng Zhang

Tedd Alan Childers

Sangita Mediratta

Mary Kathryn Olsen

Robert John Yancey, Jr

Nancee Lois Oien

Mark D Goodyear

Michael J Huether

This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions containing an antigen combined with such emulsions intrinsically or extrinsically. Methods of preparing the emulsions and vaccines are also provided by the present invention.

Microfluidized oil-in-water emulsions and vaccine compositions

This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.

Adjuvant compositions

Heat treated bacterins, a method of producing heat treated bacterins, and emulsion vaccines prepared from such heat treated bacterins are disclosed.

Heat treated bacterins, and emulsion vaccines prepared from such heat treated bacterins

This invention relates to compositions and methods of preparing stable adjuvant diluent stock solutions and final adjuvant solutions comprising glycolipids, weak acids, alcohols, nonionic surfactants and buffers.

Glycolipid adjuvant compositions

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Kalamazoo, MI, United States of America

Ramasamy M Mannan